ABSTRACT
Background:Psoriasis is an autoimmune disorder with clinical manifestations scales, inflammation and dryness. The psoriatic skin behaves differently in concurrence with circadian rhythm. Cell division increases in late night and early morning hours. Enzymatic activity will be more during day time. To balance these variations a 24×7 protection is required. The objective of the present study is to find the improvement in Psoriasis condition with the Combination therapy compared to single drug usage.Methods:A clinical trial for 4 weeks was conducted among psoriasis patients with psorolin oil vs. combination therapy (Dr.JRK’s 777 oil, psorolin ointment, psorolin oil and psorolin medicated bathing bar) and the clinical relief was measured among both groups by following parameters like psoriasis area and severity index (PASI), Physician’s global assessment (PGA), dermatology life quality index (DLQI), subjective self-assessment questionnaire (SSAQ) and subject investigational product feedback questionnaire (SIPFBQ).Results:Combination therapy (1-3-2 topical therapy) of Dr.JRK’s 777 oil, psorolin ointment, psorolin oil and psorolin medicatedbathing bar as a treatment regimen was found to be more effective in the treatment of psoriasis. Conclusions: 1-3-2 topical therapy is useful in severe psoriasis conditions and recommended for long term effective treatment of psoriasis